The Yang Lab is using a variety of molecular, cellular, pharmacologic approaches, and in vivo models to dissect the functions of histone demethylases and other histone modifiers in pediatric cancers. We are also collaborating with Department of Chemical Biology and Therapeutics to screen histone demethylase inhibitors for cancer treatment in addition to running advanced analytical techniques (RNA-Seq, ChIP-Seq, ATAC-Seq).
To be a successful Associate Scientist in the lab, you will need the ability to manage multiple projects efficiently. You are expected to have the ability to perform colony management, genotyping, routine dissections, generation of tumor xenografts, drug dosing of disease models, epigenetic target validation, basic molecular biology skills (cloning, qPCR, Western blot), and CRISPR-Cas9. In this role, you will assist in managing the daily operations of the laboratory and will train new employees as needed. Experience with NGS and bioinformatics analysis is a plus. Applicants with a strong publication record as evidence of their accomplishments are encouraged to apply.
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