Molecular classification of rare pediatric tumors and functional analysis of genetic alterations.
This is an exciting career opportunity for a mid-level scientist to join the laboratory of Dr. Lu Wang, MD, PhD, at St. Jude Children's Research Hospital. The Wang laboratory studies genetic/genomic and epigenetic changes of rare tumors with poorly understood genetics using high-resolution, genome-wide approaches, such as whole genome sequencing, whole transcriptome sequencing, methylation array, etc., with an emphasis on clinical translation of potential diagnostic markers and therapeutic targets; and addresses questions in tumorigenesis of recurrent genetic aberrations using in vitro and in vivo experimental approaches.
To succeed in this position, you should have a demonstrated proficiency in basic molecular and cell biology techniques such as DNA/RNA/protein extraction, PCR-based techniques, cell culture, cell transfection, as well as skills in generating and maintaining preclinical models. In addition, experience in cfDNA and/or cfRNA extraction is highly desired. Previous experience in analyzing data of WGS, WES, RNA-Seq and methylation array, and/or in CRISPR-Cas9 genome editing is preferred for exceptional applicants.
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